| Autor: |
Li W; Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA., Sakamuri RM, Lyons DE, Orcullo FM, Shinde V, Dela Pena EL, Maghanoy AA, Mallari IB, Tan EV, Nath I, Brennan PJ, Balagon M, Vissa V |
| Jazyk: |
angličtina |
| Zdroj: |
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2011 Nov; Vol. 55 (11), pp. 5384-7. Date of Electronic Publication: 2011 Aug 22. |
| DOI: |
10.1128/AAC.05236-11 |
| Abstrakt: |
Drug resistance surveillance identified six untreated leprosy patients in the Philippines with Mycobacterium leprae folP1 mutations which confer dapsone resistance. Five patients share a village of residence; four who carried the mutation, Thr53Val, were also linked by M. leprae variable-number tandem repeat (VNTR) strain types. In India, folP1 mutations were detected in two relapse patients with a history of dapsone treatment. Mutations were not found in the rifampin target gene rpoB. These findings indicate that dapsone resistance is being transmitted. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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