| Autor: |
Martins AN; Laboratório de Virologia Molecular, Department of Genetics, Federal University of Rio de Janeiro, Rio de Janiero, Brazil., Arruda MB, Aleixo AW, Pires AF, Greco DB, de M Brindeiro R, Tanuri A |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2011 Aug; Vol. 57 Suppl 3, pp. S193-6. |
| DOI: |
10.1097/QAI.0b013e31821e9cf6 |
| Abstrakt: |
Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are potent and well tolerated. In Brazil, the first-generation NNRTI efavirenz is included in the majority of first-line antiretroviral treatment regimens. In this study, we evaluated the effectiveness of etravirine, a new second-generation NNRTI, among patients failing antiretroviral regimens containing first-generation NNRTIs. We assessed single resistance mutations to etravirine as well as complex resistance mutations profile and discuss the potential of introducing etravirine as salvage therapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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