Genome-wide association analysis of incident coronary heart disease (CHD) in African Americans: a short report.
| Autor: | Barbalic M; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA., Reiner AP, Wu C, Hixson JE, Franceschini N, Eaton CB, Heiss G, Couper D, Mosley T, Boerwinkle E |
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| Jazyk: | angličtina |
| Zdroj: | PLoS genetics [PLoS Genet] 2011 Aug; Vol. 7 (8), pp. e1002199. Date of Electronic Publication: 2011 Aug 04. |
| DOI: | 10.1371/journal.pgen.1002199 |
| Abstrakt: | African Americans have the highest rate of mortality due to coronary heart disease (CHD). Although multiple loci have been identified influencing CHD risk in European-Americans using a genome-wide association (GWAS) approach, no GWAS of incident CHD has been reported for African Americans. We performed a GWAS for incident CHD events collected during 19 years of follow-up in 2,905 African Americans from the Atherosclerosis Risk in Communities (ARIC) study. We identified a genome-wide significant SNP (rs1859023, MAF = 31%) located at 7q21 near the PFTK1 gene (HR = 0.57, 95% CI 0.46 to 0.69, p = 1.86×10(-08)), which replicated in an independent sample of over 8,000 African American women from the Women's Health Initiative (WHI) (HR = 0.81, 95% CI 0.70 to 0.93, p = 0.005). PFTK1 encodes a serine/threonine-protein kinase, PFTAIRE-1, that acts as a cyclin-dependent kinase regulating cell cycle progression and cell proliferation. This is the first finding of incident CHD locus identified by GWAS in African Americans. Competing Interests: The authors have declared that no competing interests exist. |
| Databáze: | MEDLINE |
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