Immunohistochemical distribution of toll-like receptor 4 in preterm human fetal membrane.

Autor: Choi SJ; Departments of Obstetrics and Gynecology Pathology Microbiology, Yonsei University, Wonju College of Medicine, Wonju, Korea., Jung SH, Eom M, Han KH, Chung IB, Kim SK
Jazyk: angličtina
Zdroj: The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2012 Jan; Vol. 38 (1), pp. 108-12. Date of Electronic Publication: 2011 Aug 10.
DOI: 10.1111/j.1447-0756.2011.01626.x
Abstrakt: Aim: Toll-like receptor 4 (TLR-4) is the major receptor used for recognition of specific gram negative bacteria by the host immune system. The role of TLR-4 has been revealed in preterm parturition. This study aims to demonstrate the immunohistochemical expression of TLR-4 with regard to histological layers and anatomical regions of the human fetal membranes.
Material and Methods: Fetal membranes were obtained from the uterine fundus and low segment. Immunohistochemical staining for TLR-4 and hematoxylin and eosin stain were performed.
Results: The chorion expressed significantly higher levels of TLR-4 than the amnion (P=0.001). There was no difference in the expression of TLR-4 between the uterine fundus and the uterine low segment (P=0.942). There was no significant difference in TLR-4 expression according to the presence of histological chorioamnionitis (P=0.444). TLR-4 expression decreased significantly with the progression of gestation (P=0.002).
Conclusions: The level of expression of TLR-4 did not differ according to anatomic location, but did differ according to the histological layer of the human fetal membranes and gestational age. These results suggest that TLR-4 may be involved in preterm parturition.
(© 2011 The Authors. Journal of Obstetrics and Gynaecology Research © 2011 Japan Society of Obstetrics and Gynecology.)
Databáze: MEDLINE
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