Effects of alcohol on highway driving in the STISIM driving simulator.
| Autor: | Mets MA; Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacology, Utrecht University, Utrecht, The Netherlands. m.a.j.mets@uu.nl, Kuipers E, de Senerpont Domis LM, Leenders M, Olivier B, Verster JC |
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| Jazyk: | angličtina |
| Zdroj: | Human psychopharmacology [Hum Psychopharmacol] 2011 Aug; Vol. 26 (6), pp. 434-9. Date of Electronic Publication: 2011 Aug 05. |
| DOI: | 10.1002/hup.1226 |
| Abstrakt: | Objective: The STISIM driving simulator is widely used. To enhance its usefulness in pharmacological research, a calibration study was performed to test a standardized highway driving test scenario after administration of three different dosages of alcohol and placebo. Methods: Twenty-seven healthy young adults (14 men and 13 women; mean age (SD) = 22.8 (1.4)) participated in this randomized, single-blind crossover trial. Subjects received alcohol to gain a blood alcohol concentration (BAC) of 0.05%, 0.08%, and 0.11%, or placebo-alcohol. In each condition, subjects completed a 100-km highway driving simulator test. The standard deviation of lateral position, the weaving of the car, was the primary parameter of the test. Results: Alcohol produced dose-dependent driving impairment. Standard deviation of lateral position and standard deviation of speed were significantly increased relative to placebo (p < 0.05). Subjective driving assessments were in line with the objective driving measurements. Conclusion: The STISIM highway driving simulator test is able to differentiate dose-dependent impairment after administration of alcohol. The highway driving test scenario is suitable for future psychopharmacological research. (Copyright © 2011 John Wiley & Sons, Ltd.) |
| Databáze: | MEDLINE |
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