| Autor: |
Oldham JW; Department of Toxicology, R.W. Johnson Pharmaceutical Research Institute at McNeil Pharmaceutical, Spring House, Pennsylvania 19477., Carson JR, Gill A, Preston RF, Sedor DD |
| Jazyk: |
angličtina |
| Zdroj: |
Fundamental and applied toxicology : official journal of the Society of Toxicology [Fundam Appl Toxicol] 1990 Feb; Vol. 14 (2), pp. 376-85. |
| DOI: |
10.1016/0272-0590(90)90217-8 |
| Abstrakt: |
A series of ortho-(arylalkynyl)phenoxypropanolamines with antihypertensive activity in laboratory animals was screened in vitro for mutagenicity using the Ames test and the mouse lymphoma assay, and for DNA damaging potential in the primary rat hepatocyte/DNA repair assay. Those compounds with a dialkylamino group on the para position of the arylalkynyl function were shown to be genotoxic in both mutagenicity assays when tested in the presence of an Aroclor 1254-induced rat liver S-9 mix. They were also active in the DNA repair assay. Removal of the para-dialkylamino group or changing the position of this group on the aryl ring eliminated the genotoxic effect in these test systems. This collaborative effort between chemists, pharmacologists, and toxicologists successfully identified the structural feature responsible for the genotoxic activity and indicated structural alterations that would yield a pharmacologically active compound with no genotoxicity in these in vitro assays. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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