| Autor: |
Kapina MA; Department of Immunology, Central Institute for Tuberculosis, Moscow, Russia., Shepelkova GS, Avdeenko VG, Guseva AN, Kondratieva TK, Evstifeev VV, Apt AS |
| Jazyk: |
angličtina |
| Zdroj: |
PloS one [PLoS One] 2011; Vol. 6 (7), pp. e21878. Date of Electronic Publication: 2011 Jul 15. |
| DOI: |
10.1371/journal.pone.0021878 |
| Abstrakt: |
IL-11 is multifunctional cytokine whose physiological role in the lungs during pulmonary tuberculosis (TB) is poorly understood. Here, using in vivo administration of specific antibodies against IL-11, we demonstrate for the first time that blocking IL-11 diminishes histopathology and neutrophilic infiltration of the lung tissue in TB-infected genetically susceptible mice. Antibody treatment decreased the pulmonary levels of IL-11 and other key inflammatory cytokines not belonging to the Th1 axis, and down-regulated IL-11 mRNA expression. This suggests the existence of a positive feedback loop at the transcriptional level, which is further supported by up-regulation of IL-11 mRNA expression in the presence of rIL-11 in in vitro cultures of lung cells. These findings imply a pathogenic role for IL-11 during the early phase of Mycobacterium tuberculosis-triggered disease in a genetically susceptible host. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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