Effect of mesoporous silica under Neisseria meningitidis transformation process: environmental effects under meningococci transformation.
| Autor: | Hollanda LM; Department of Biochemistry, Institute of Biology CP6109, State University of Campinas UNICAMP, CP: 6109-CEP 13083-970, Campinas, SP, Brazil., Cury GC, Pereira RF, Ferreira GA, Sousa A, Sousa EM, Lancellotti M |
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| Jazyk: | angličtina |
| Zdroj: | Journal of nanobiotechnology [J Nanobiotechnology] 2011 Jul 25; Vol. 9, pp. 28. Date of Electronic Publication: 2011 Jul 25. |
| DOI: | 10.1186/1477-3155-9-28 |
| Abstrakt: | Background: This study aimed the use of mesoporous silica under the naturally transformable Neisseria meningitidis, an important pathogen implicated in the genetic horizontal transfer of DNA causing a escape of the principal vaccination measures worldwide by the capsular switching process. This study verified the effects of mesoporous silica under N. meningitidis transformation specifically under the capsular replacement. Methods: we used three different mesoporous silica particles to verify their action in N. meningitis transformation frequency. Results: we verified the increase in the capsular gene replacement of this bacterium with the three mesoporous silica nanoparticles. Conclusion: the mesouporous silica particles were capable of increasing the capsule replacement frequency in N. meningitidis. |
| Databáze: | MEDLINE |
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