[Detection of large deletions of mitochondrial DNA in tissues of mice exposed to X-rays].

Autor: Antipova VN, Malakhova LV, Bezlepkin VG
Jazyk: ruština
Zdroj: Biofizika [Biofizika] 2011 May-Jun; Vol. 56 (3), pp. 439-45.
Abstrakt: Large mtDNA deletions in mouse brain and spleen cells, induced by X-radiation at doses of 2 and 5 Gy were studied within four weeks after the exposure of animals to X-rays. Variations in the content of extracellular (deletion) mtDNA were examined in the blood plasma of mice irradiated with 5 Gy in the same postirradiation times. Ionizing radiation was shown to effectively induce large mtDNA deletions at the doses chosen. The level of deletion mtDNA was dependent on dose and postirradiation time.
Databáze: MEDLINE