| Autor: |
Jones RN; Anti-infective Research Center, University of Iowa Hospitals and Clinics, Iowa City., Croco JL, Barrett MS, Novick WJ Jr, Erwin ME |
| Jazyk: |
angličtina |
| Zdroj: |
Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 1990 Sep-Oct; Vol. 13 (5), pp. 371-3. |
| DOI: |
10.1016/0732-8893(90)90004-f |
| Abstrakt: |
Cefpirome, a so-called fourth-generation cephalosporin, was tested alone and in combination with the sulfone beta-lactamase inhibitor, tazobactam, against 63 members of the Bacteroides fragilis group. The cefpirome MIC50 was only 64 micrograms/ml, but the MIC was reduced eightfold with tazobactam (2:1 ratio). The addition of tazobactam to cefpirome or the use of metronidazole as a codrug appear to be alternative choices to enhance the antianaerobic spectrum. Over 98% of strains had cefpirome-tazobactam MICs of less than or equal to 32 micrograms/ml. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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