[Study of the GABA-benzodiazepine receptor system of the human myometrium].

Autor: Sergeev PV, Sizov PI, Dukhanin AS, Mineeva EN
Jazyk: ruština
Zdroj: Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1990 Oct; Vol. 110 (10), pp. 382-4.
Abstrakt: A specific [3H] GABA and [14C] flunitrazepam binding sites have been identified in a membrane fraction of human myometrium. The specific binding of [14C] GABA was displaced by unlabelled GABA and bicuculline. It was shown that the binding of [3H] flunitrazepam to membrane preparations is enhanced in the presence of GABA. A similar reciprocal effect of benzodiazepines to enhance [14C] GABA binding has been demonstrated. The present results indicate that GABAA-BD receptors complexes may have a functional significance in human ovary.
Databáze: MEDLINE