Specific inflammatory microenvironments in the zones of the fetal membranes at term delivery.

Autor: Gomez-Lopez N; Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico. gomezlop@ualberta.ca, Vadillo-Perez L, Hernandez-Carbajal A, Godines-Enriquez M, Olson DM, Vadillo-Ortega F
Jazyk: angličtina
Zdroj: American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2011 Sep; Vol. 205 (3), pp. 235.e15-24. Date of Electronic Publication: 2011 Apr 16.
DOI: 10.1016/j.ajog.2011.04.019
Abstrakt: Objective: The purpose of this study was to examine the histologic and immunologic differences between fetal membrane zones after membrane rupture at term delivery.
Study Design: Fetal membrane explants from postrupture zones (periplacental, middle, rupture) were obtained from women following spontaneous vaginal delivery at term (n = 5). Tissues for histology, protein extracts, and RNA were isolated.
Results: The collagen distribution decreased and the leukocyte density increased from the periplacental zone to the rupture zone. T cells were mainly present in the rupture zone and granulocytes in the middle zone. CXCL10, CXCR1, ICAM-1, -2, PSEL, tumor necrosis factor alpha, and matrix metalloproteinase-9 levels were higher in the middle zone than in the rupture zone and periplacental zone (P < .021). Interleukin-1beta and CXCL8 levels were higher in the rupture zone than in the middle zone and periplacental zone (P = .018 and P < .0001).
Conclusion: During labor specific immunologic microenvironments are created in the zones of the fetal membrane that may be involved in their rupture at the end of gestation.
(Copyright © 2011 Mosby, Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: