6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators.
| Autor: | Weiss JM; Chemical & Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA., Jimenez HN, Li G, April M, Uberti MA, Bacolod MD, Brodbeck RM, Doller D |
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| Jazyk: | angličtina |
| Zdroj: | Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Aug 15; Vol. 21 (16), pp. 4891-9. Date of Electronic Publication: 2011 Jun 17. |
| DOI: | 10.1016/j.bmcl.2011.06.014 |
| Abstrakt: | A series of 6-aryl-3-pyrrolidinylpyridine analogs was explored as structurally novel negative allosteric modulators of the mGlu5 receptor lacking an alkyne or oxadiazole moiety. Compounds in this series were characterized by tractable SAR, good in vitro potencies and brain penetration in rodents. (Copyright © 2011 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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