| Autor: |
Groves RB; School of Engineering, Cardiff University, Queen's Buildings, The Parade, Cardiff, CF24 3AA, UK. sce5rbg@cardiff.ac.uk, Coulman SA, Birchall JC, Evans SL |
| Jazyk: |
angličtina |
| Zdroj: |
Computer methods in biomechanics and biomedical engineering [Comput Methods Biomech Biomed Engin] 2012; Vol. 15 (1), pp. 73-82. Date of Electronic Publication: 2011 Jul 12. |
| DOI: |
10.1080/10255842.2011.596481 |
| Abstrakt: |
Microneedle devices are a promising minimally invasive means of delivering drugs/vaccines across or into the skin. However, there is currently a diversity of microneedle designs and application methods that have, primarily, been intuitively developed by the research community. To enable the rational design of optimised microneedle devices, a greater understanding of human skin biomechanics under small deformations is required. This study aims to develop a representative stratified model of human skin, informed by in vivo data. A multilayer finite element model incorporating the epidermis, dermis and hypodermis was established. This was correlated with a series of in-vivo indentation measurements, and the Ogden material coefficients were optimised using a material parameter extraction algorithm. The finite element simulation was subsequently used to model microneedle application to human skin before penetration and was validated by comparing these predictions with the in-vivo measurements. Our model has provided an excellent tool to predict micron-scale human skin deformation in vivo and is currently being used to inform optimised microneedle designs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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