Calculation of the inactivation cross section of v79 cells by protons in radiotherapy.
| Autor: | Azooz FA; Department of Physics, College of Education, University of Mosul, Iraq., Alkhalidy TJ |
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| Jazyk: | angličtina |
| Zdroj: | Sultan Qaboos University medical journal [Sultan Qaboos Univ Med J] 2007 Dec; Vol. 7 (3), pp. 233-8. |
| Abstrakt: | Objective: For efficient applications of protons in radiotherapy, detailed knowledge of the corresponding radiobiological mechanism is necessary. The inactivation cross section is a useful tool to explore the interaction mechanism. Hence, the inactivation cross section for proton irradiation on V79 cells has been calculated using published survival data. Method: The linear quadratic equation was used to fit the survival curves and the parameter α was used to calculate the cross section. The cross section σ is plotted as a function of the mean free path λ and the linear energy transfer LET. Results: The cross section σ-versus-λ curve shows a saturation region between λ≥2 nm and λ≤5 nm. In this region, the inactivation cross section value is about the same as the geometrical area of the DNA segment (≈4 μm(2)). Such a saturation is also seen in the σ-LET curve. Conclusion: This implies that one DNA segment is at a risk upon the traversal of a single proton. |
| Databáze: | MEDLINE |
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