| Autor: |
Bissett D; CRC Department of Medical Oncology, Beatson Oncology Centre, Western Infirmary, Glasgow, UK., Kunkeler L, Zwanenburg L, Paul J, Gray C, Swan IR, Kerr DJ, Kaye SB |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of cancer [Br J Cancer] 1990 Oct; Vol. 62 (4), pp. 655-9. |
| DOI: |
10.1038/bjc.1990.350 |
| Abstrakt: |
Seventy-four patients previously treated in our department for germ cell tumour of the testis underwent a series of tests to determine the frequency of long-term therapeutic complications. All had received cisplatin-based chemotherapy as part of their treatment. There was a significant deterioration in renal function throughout the group. Eighteen (24%) had supine blood pressure greater than systolic 140 mmHg or diastolic 90 mmHg after treatment but hypertension did not correlate with renal impairment. Raynaud's phenomenon was common after chemotherapy (26/74) as was persistent sensory neuropathy (23/74). Although 34% had testosterone levels below the normal range, only six patients had a low free testosterone index with one testis still in situ; 18 patients have fathered children after chemotherapy. Approximately half of the patients completed a psychosexual questionnaire and some 30% of them admitted to sexual problems which they attributed to their treatment. Long-term sequelae of cisplatin-based chemotherapy for testicular malignancy are frequent and persistent, and follow-up of these patients should include prospective measurement of changes in blood pressure. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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