| Autor: |
Cáceres L; Banting and Best Department of Medical Research, Department of Molecular Biology, University of Toronto, Ontario, Canada., Necakov AS, Schwartz C, Kimber S, Roberts IJ, Krause HM |
| Jazyk: |
angličtina |
| Zdroj: |
Genes & development [Genes Dev] 2011 Jul 15; Vol. 25 (14), pp. 1476-85. Date of Electronic Publication: 2011 Jun 29. |
| DOI: |
10.1101/gad.2064111 |
| Abstrakt: |
Nitric oxide gas acts as a short-range signaling molecule in a vast array of important physiological processes, many of which include major changes in gene expression. How these genomic responses are induced, however, is poorly understood. Here, using genetic and chemical manipulations, we show that nitric oxide is produced in the Drosophila prothoracic gland, where it acts via the nuclear receptor ecdysone-induced protein 75 (E75), reversing its ability to interfere with its heterodimer partner, Drosophila hormone receptor 3 (DHR3). Manipulation of these interactions leads to gross alterations in feeding behavior, fat deposition, and developmental timing. These neuroendocrine interactions and consequences appear to be conserved in vertebrates. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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