| Autor: |
Kamat NP; Departments of Bioengineering and Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19103 (USA)., Robbins GP, Rawson JS, Therien MJ, Dmochowski IJ, Hammer DA |
| Jazyk: |
angličtina |
| Zdroj: |
Advanced functional materials [Adv Funct Mater] 2010 Aug 23; Vol. 20 (16), pp. 2588-2596. |
| DOI: |
10.1002/adfm.201000659 |
| Abstrakt: |
Polymersomes are vesicles whose membranes are comprised of self-assembled block co-polymers. We recently showed that co-encapsulating conjugated multi-porphyrin dyes in a polymersome membrane with ferritin protein in the aqueous lumen confers photo-lability to the polymersome. In the present study, we illustrate that the photo-lability can be extended to vesicles containing dextran, an inert and inexpensive polysaccharide, as the luminal solute. Here we explore how structural features of the polymersome/porphyrin/dextran composite affect its photo-response. Increasing dextran molecular weight, decreasing block copolymer molecular weight, and altering fluorophore-membrane interactions results in increasing the photo-responsiveness of the polymersomes. Amphiphilic interactions of the luminal encapsulant with the membrane coupled with localized heat production in the hydrophobic bilayer likely cause differential thermal expansion in the membrane and the subsequent membrane rupture. This study suggests a general approach to impart photo-responsiveness to any biomimetic vesicle system without chemical modification, as well as a simple, bio-inert method for constructing photo-sensitive carriers for controlled release of encapsulants. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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