Anxiolytic effect of midazolam premedication assessed by clinical and platelet aggregation profiles.
| Autor: | Khan EI; Department of Anaesthesia & Intensive Care, Aga Khan University, Karachi, Pakistan., Kamal RS, Ullah H |
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| Jazyk: | angličtina |
| Zdroj: | Journal of Ayub Medical College, Abbottabad : JAMC [J Ayub Med Coll Abbottabad] 2010 Apr-Jun; Vol. 22 (2), pp. 4-7. |
| Abstrakt: | Background: It is well documented that surgery is associated with increased anxiety, which has an adverse impact on patient's outcome. This study was designed to assess the anxiolytic effect of midazolam in pre-anaesthetic medication by using clinical and platelet aggregation profiles. Methods: Sixty ASA I and II female patients aged between 35 and 60 years undergoing elective abdominal hysterectomy were randomly divided into two equal groups. Group I received placebo as pre-medication while group II received 0.15 mg/kg midazolam as pre-medication 1 hour preoperatively. They were monitored for visual analogue scale (VAS) for anxiety, observer's anxiety criteria, sedation score, blood pressure, heart rate and platelet aggregation profile immediately before and 1 hour after pre-medication. Results: There was statistically significant difference with respect to VAS of anxiety, observer's anxiety criteria, sedation scores, systolic and diastolic blood pressure (p<0.05). Heart rate was higher in the midazolam group but this was not statistically significant. There was no statistical significant difference in platelet aggregation profile in the two groups. Conclusion: Findings of the study suggest midazolam is a good anxiolytic for pre-medication and its effect on platelet aggregation profile needs to be further evaluated. |
| Databáze: | MEDLINE |
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