Expression of cyclooxygenase-2 (COX-2) and p53 in neighboring invasive and in situ components of breast tumors.

Autor: Serra KP; Department of Obstetrics and Gynecology, State University of Campinas - Unicamp, Campinas, São Paulo, Brazil., Sarian LO, Rodrigues-Peres RM, Vassallo J, Soares FA, Pinto GA, da Cunha IW, Shinzato JY, Derchain SF
Jazyk: angličtina
Zdroj: Acta histochemica [Acta Histochem] 2012 May; Vol. 114 (3), pp. 226-31. Date of Electronic Publication: 2011 Jun 16.
DOI: 10.1016/j.acthis.2011.05.001
Abstrakt: The aim of the study was to assess the relationship between the expression of COX-2 and p53, hormone receptors and HER-2 in the in situ (DCIS) and invasive components of ductal carcinomas (IDC) of the same breast. The expression of COX-2, p53, and hormone receptors was assessed in 87 cases of IDC with contiguous areas of DCIS. Results showed that there was no difference in COX-2 expression comparing the in situ and invasive components of the tumors. In the in situ component, there was a statistically borderline increase in p53 expression in tumors that also expressed COX-2. ER-positive specimens were more common in the group of tumors that expressed COX-2 in the invasive component. From this study we conclude that the expression of COX-2 was similar in the in situ and invasive components of the breast carcinomas. COX-2 positivity was marginally related with the expression of p53 in the in situ components, and with the ER expression in the invasive components.
(Copyright © 2011 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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