Bacterial vaginosis as a risk factor for high-grade cervical lesions and cancer in HIV-seropositive women.

Autor: Denslow SA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, USA., Westreich DJ, Firnhaber C, Michelow P, Williams S, Smith JS
Jazyk: angličtina
Zdroj: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2011 Sep; Vol. 114 (3), pp. 273-7. Date of Electronic Publication: 2011 Jun 16.
DOI: 10.1016/j.ijgo.2011.03.011
Abstrakt: Objective: To assess the effect of bacterial vaginosis (BV) on the risk of high-grade squamous intraepithelial lesions (HSIL) among HIV-seropositive women.
Methods: A hospital-based prospective cohort study of HIV-seropositive women was conducted in Johannesburg, South Africa from January 2005 to September 2009. Multivariate log-binomial and Poisson regressions were used to estimate prevalence and rate ratios, respectively.
Results: Among 1954 HIV-seropositive women, the baseline prevalence of HSIL was 17%. BV prevalence was high (54%) and showed no association with prevalence of HSIL (adjusted prevalence ratio, 1.12; 95% confidence intervals (CI), 0.92-1.35) nor with cervical lesion progression at follow-up visit (n=503) (adjusted rate ratio: 1.00; 95% CI, 0.65-1.53).
Conclusion: Among HIV-seropositive women, BV was not associated with an increased risk of HSIL or cervical lesion progression.
(Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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