Do infants increase the risk of re-emergent infection in households after mass drug administration for trachoma?

Autor: West SK; Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland 21287-9019, USA. shwest@jhmi.edu, Stare D, Mkocha H, Munoz B, Gaydos C, Quinn TC
Jazyk: angličtina
Zdroj: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2011 Jul 29; Vol. 52 (8), pp. 6040-2. Date of Electronic Publication: 2011 Jul 29.
DOI: 10.1167/iovs.11-7372
Abstrakt: Purpose: Mass treatment with azithromycin for trachoma endemic communities typically excludes infants under age 6 months, whose parents are provided with tubes of tetracycline to administer daily over 4 to 6 weeks. The authors sought to determine whether infants aged <6 months are a source of re-emergent infection in their families after mass treatment in trachoma-endemic communities.
Methods: In a longitudinal study of all children aged less than 10 years in four communities, the authors identified 91 infants aged <6 months living in 86 of 1241 households. All children aged Results: The prevalence of infection at baseline in the infants was 5.9%. At 6 months post mass drug administration, the rate of infection among children older than 6 months and less than 10 years who resided in households with infants was 6.0% compared with 11.1% in children in households without infants (P = 0.18). After adjustment for age, sex, baseline infection status, and treatment, residing in a household with an infant was not associated with infection at 6 months (odds ratio [95% confidence interval] 0.50 [0.20-1.22]).
Conclusions: This prospective study did not find evidence that living in a household with an infant increased the risk of infection 6 months post mass drug administration in other children residing in the household.
Databáze: MEDLINE
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