[Polymorphic variants of ALOX5AP gene and the risk of acute stroke development in the Russian population].

Autor: Bondarenko EA, Slominskiĭ PA, Limborskaia SA, Shetova IM, Timofeev DY, Skvortsova VI
Jazyk: ruština
Zdroj: Genetika [Genetika] 2011 Apr; Vol. 47 (4), pp. 570-3.
Abstrakt: A protein capable of activating 5-lipoxygenase (ALOX5AP) is considered a presumable risk factor of acute stroke development. Polymorphic variants of the ALOX5AP gene were examined. Two ALOX5AP gene polymorphisms (SG13S114 (rs10507391) and SG13S32 (rs9551963)), which previously had shown association with the risk of ischemic stroke in other populations, were studied. These single nucleotide polymorphisms were analyzed using a sample of acute stroke patients (N = 1320) and a control sample (N = 467). No statistically significant associations were found between acute stroke and the ALOX5AP gene polymorphisms examined.
Databáze: MEDLINE