N-Acetylcysteine protects the peritoneum from the injury induced by hypertonic dialysis solution.

Autor:	Bui DS; Faculty of Medicine, University of São Paulo, São Paulo, Brazil., Seguro AC, Shimitzu MH, Schliemann I, Martini D, Romão JE Jr, Pecoits Filho RF, Abensur H
Jazyk:	angličtina
Zdroj:	Journal of nephrology [J Nephrol] 2012 Jan-Feb; Vol. 25 (1), pp. 90-5.
DOI:	10.5301/JN.2011.8404
Abstrakt:	Background: Oxidative stress has been implicated in the development of peritoneal damage. The aim of this study was to evaluate the effects of N-acetylcysteine (NAC) in a rat peritoneal infusion model. Methods: Eighteen male Wistar rats were divided in 3 groups: (i) control group; (ii) HDS group, receiving peritoneal dialysis solution (PDS); and (iii) HDS+NAC group, receiving PDS and oral NAC. Six weeks later they were evaluated for dialysate to plasma urea ratio (D/P), ratio of glucose concentration in peritoneal fluid (G1/G0), thiobarbituric acid reactive substances in plasma and urine and histology of peritoneal membrane. Results: The HDS+NAC group presented a lower increase in solute transport (D/P 0.51 ± 0.1, and G1/GO 0.35 ± 0.06) in comparison with the HDS group (D/P 0.67 ± 0.1; p=0.03, and G1/G0 0.27 ± 0.07; p=0.01). The HDS+NAC group showed lower thiobarbituric acid reactive substance concentrations compared with the HDS group. In the treated group, the peritoneal membrane presented lower thickness. Conclusions: Functional and histological peritoneal changes were significantly reduced by the treatment with NAC.
Databáze:	MEDLINE
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