Prognostic implications of parathyroid hormone-related protein in males and females with non--small-cell lung cancer.

Autor: Montgrain PR; Research, Anesthesiology and Medicine Services, VA San Diego Healthcare System, San Diego, CA 92161, USA., Deftos LJ, Arenberg D, Tipps A, Quintana R, Carskadon S, Hastings RH
Jazyk: angličtina
Zdroj: Clinical lung cancer [Clin Lung Cancer] 2011 May; Vol. 12 (3), pp. 197-205. Date of Electronic Publication: 2011 Apr 24.
DOI: 10.1016/j.cllc.2011.03.018
Abstrakt: Background: Non-small-cell lung carcinoma immunoreactivity for parathyroid hormone-related protein has been associated with increased survival in female patients but not in male patients. The current investigation attempted to substantiate this finding in 2 new patient groups.
Methods: Patients were divided into groups with and without immunoreactivity for a carboxyl-terminal parathyroid hormone-related protein epitope assessed in deparaffinized sections by a blinded observer. One group included 85 female patients with stage I lung cancer, and the second group had 48 female and 66 male patients with stage I-IV lung cancer. Survival times were compared by the log-rank test between groups separated by tumor parathyroid hormone-related protein status.
Results: Parathyroid hormone-related protein was present in 70%-80% of the patients, independent of sex, stage, and smoking history. In the females with stage I lung cancer, parathyroid hormone-related protein increased median survival from 25 to 60 months (P < .05). In the second group, parathyroid hormone-related protein expression increased 48-month disease-free survival of female lung cancer patients from 44% to 63% (P < .05), but had no effect in male patients. Parathyroid hormone-related protein remained a significant, independent predictor when evaluated together with other covariates by Cox multivariate regression.
Conclusion: This study verifies that parathyroid hormone-related protein is a sex-dependent survival factor for non-small-cell lung carcinoma, that it correlates with disease-free survival, and that the association with survival holds for women with early-stage disease as well as more advanced cancer. Thus, the protein could find use as a prognostic indicator and could be a target for therapy.
(Copyright © 2011 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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