Endemic tegumentary leishmaniasis in Brazil: correlation between level of endemicity and number of cases of mucosal disease.

Autor: Bedoya-Pacheco SJ; Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Av. Brasil 4365, Manguinhos, Rio de Janeiro, Brazil. sandro.bedoya@ipec.fiocruz.br, Araujo-Melo MH, Valete-Rosalino CM, Pimentel MI, Conceição-Silva F, Schubach AO, Marzochi MC
Jazyk: angličtina
Zdroj: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2011 Jun; Vol. 84 (6), pp. 901-5.
DOI: 10.4269/ajtmh.2011.10-0595
Abstrakt: The purpose of this study was to establish a correlation between the endemic level of tegumentary leishmaniasis in different regions of Brazil during 2002-2009 and the number of cases of mucosal or mucocutaneous leishmaniasis. The proportion of mucosal leishmaniasis was inversely correlated with prevalence of infection. In areas with a lower infection prevalence, the proportion of mucosal leishmaniasis increased (P < 0.05). The hypothesis of an Amazonian origin and dissemination through human migration is considered. Our results show that in regions with lower prevalence and endemically younger, the proportion of cases that evolve to the mucosal form is higher than in regions with higher prevalence and endemically older.
Databáze: MEDLINE