| Autor: |
Dronda F; Servicio de Enfermedades Infecciosas, Hospital Ramón y Cajal, Carretera de Colmenar, Madrid, Spain. fdronda.hrc@salud.madrid.org, Sobrino P, Hernández-Novoa B, Caro-Murillo AM, Montero M, Iribarren JA, Sanz J, Del Mar Alonso M, Labarga P, Bernal E, Moreno S |
| Jazyk: |
angličtina |
| Zdroj: |
Current HIV research [Curr HIV Res] 2011 Jun; Vol. 9 (4), pp. 229-36. |
| DOI: |
10.2174/157016211796320324 |
| Abstrakt: |
We aimed to evaluate immunological, virological and clinical response to HAART, as well as all-cause mortality, in treatment-naive patients with a diagnosis of tuberculosis (TB) in the prior 6 months, compared to subjects with another AIDS-defining illness (ADI) or event-free individuals in an open, prospective and multicenter hospital-based cohort of HIV-infected naive adults (2004-2008). All cause mortality rates were calculated by Cox regression models. Among 4407 patients, 2400 (54.5%) started HAART: 110 (4.6%) had had previous TB and 414 (17.3%) another ADI. Median time from TB diagnosis to inititation of HAART was 53 days (IQR: 25.75-83.25), and for other ADI was 22 days (IQR: 8-42). Overall, 151 (6.3%) patients developed a new ADI during follow-up; 63% reached virological suppression and 69.4% had increases of ≥50 CD4+/µl, at 6 months. No statistically significant differences were found according to a previous history of TB or another ADI. Overall, 85 subjects died in 4031 person-years of follow-up with a mortality rate of 2.1 (95%CI: 1.7-2.6). When compared to subjects who started HAART in the absence of a previous ADI (HR 1), a prior diagnosis of an ADI other than TB was significantly associated with an increased risk of death. (HR 1.6; 95%CI: 1.1-2.3), but not a diagnosis of TB (HR 1.15; 95%CI: 0.5-2.5). In conclusion, a previous diagnosis of TB or another ADI before HAART did not compromise short-term virological and immunological response to treatment. A prior diagnosis of an ADI different to TB significantly increased all cause mortality. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
