Kinematics of cervical total disc replacement adjacent to a two-level, straight versus lordotic fusion.

Autor:	Martin S; Loyola University Stritch School of Medicine, Maywood, IL, USA., Ghanayem AJ, Tzermiadianos MN, Voronov LI, Havey RM, Renner SM, Carandang G, Abjornson C, Patwardhan AG
Jazyk:	angličtina
Zdroj:	Spine [Spine (Phila Pa 1976)] 2011 Aug 01; Vol. 36 (17), pp. 1359-66.
DOI:	10.1097/BRS.0b013e318222d4ad
Abstrakt:	Study Design: In vitro biomechanical study. Objective: To characterize cervical total disc replacement (TDR) kinematics above two-level fusion, and to determine the effect of fusion alignment on TDR response. Summary of Background Data: Cervical TDR may be a promising alternative for a symptomatic adjacent level after prior multilevel cervical fusion. However, little is known about the TDR kinematics in this setting. Methods: Eight human cadaveric cervical spines (C2-T1, age: 59 ± 8.6 years) were tested intact, after simulated two-level fusion (C4-C6) in lordotic alignment and then in straight alignment, and after C3-C4 TDR above the C4-C6 fusion in lordotic and straight alignments. Fusion was simulated using an external fixator apparatus, allowing easy adjustment of C4-C6 fusion alignment, and restoration to intact state upon disassembly. Specimens were tested in flexion-extension using hybrid testing protocols. Results: The external fixator device significantly reduced range of motion (ROM) at C4-C6 to 2.0 ± 0.6°, a reduction of 89 ± 3.0% (P < 0.05). Removal of the fusion construct restored the motion response of the spinal segments to their intact state. The C3-C4 TDR resulted in less motion as compared to the intact segment when the disc prosthesis was implanted either as a stand-alone procedure or above a two-level fusion. The decrease in motion of C3-C4 TDR was significant for both lordotic and straight fusions across C4-C6 (P < 0.05). Flexion and extension moments needed to bring the cervical spine to similar C2 motion endpoints significantly increased for the TDR above a two-level fusion compared to TDR alone (P < 0.05). Lordotic fusion required significantly greater flexion moment, whereas straight fusion required significantly greater extension moment (P < 0.05). Conclusion: TDR placed adjacent to a two-level fusion is subjected to a more challenging biomechanical environment as compared to a stand-alone TDR. An artificial disc used in such a clinical scenario should be able to accommodate the increased moment loads without causing impingement of its endplates or undue wear during the expected life of the prosthesis.
Databáze:	MEDLINE
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