Health-related quality of life scores in long-term head and neck cancer survivors predict subsequent survival: a prospective cohort study.
| Autor: | Osthus AA; Department of Surgical Sciences, Faculty of Medicine, University of Bergen, Bergen, Norway., Aarstad AK, Olofsson J, Aarstad HJ |
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| Jazyk: | angličtina |
| Zdroj: | Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery [Clin Otolaryngol] 2011 Aug; Vol. 36 (4), pp. 361-8. |
| DOI: | 10.1111/j.1749-4486.2011.02342.x |
| Abstrakt: | Objective: To examine the survival prediction of long-term health-related quality of life in patients with head and neck squamous cell carcinoma. Design: Patients with head and neck squamous cell carcinoma diagnosed in the period between July 1992 and October 2001, who had been disease free for a minimum of 1 year following therapy, responded to structured interviews including several validated questionnaires in the period from October 2002 to March 2004. The study ended in June 2009 with a mean observation time of 75 ± 4 months among the survivors. Twenty-four deaths were observed. Setting: University hospital, referral centre of the Western Norway. Participants: One hundred and thirty-nine cognitive functioning patients. Main Outcome Measurements: Overall survival as of June 2009. This was correlated with various clinical factors and the EORTC QLQ-C30 questionnaire, the Eysenck Personality Inventory and the Coping inventory completed between October 2001 and March 2004. Results: A general symptom sum score was significantly predictive of survival directly and after sequential adjustment for self-reported levels of neuroticism, avoidance focused coping, coping by suppression of competing activity, alcohol consumption, smoking status and heart/lung disease, as well as gender, age, time between diagnosis and inclusion, tumour node metastasis (TNM) stage and tumour site. Similar results were found for the health-related quality of life indices 'fatigue', 'dyspnoea' and 'sleep disturbance'. A dichotomised variable based on the general symptom sum score was calculated, and a high risk group, as to mortality, including less than a quintile of the total patient population was established. A hazard ratio of 5.15 was found for the dichotomised general symptom sum score. Conclusion: We have shown a unique and independent survival prediction from long-term EORTC QLQ-C30 scores in successfully treated and cognitive functioning head and neck squamous cell carcinoma patients. (© 2011 Blackwell Publishing Ltd.) |
| Databáze: | MEDLINE |
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