Non-human leukocyte antigen antibodies reactive with endothelial cells could be involved in early loss of renal allografts.

Autor: Ronda C; Laboratory of Immunology, Heart Institute, School of Medicine, University of São Paulo, São Paulo, Brazil. cronda51@hotmail.com, Borba SC, Ferreira SC, Glotz D, Ianhez LE, Rodrigues H, Viggiani CS, Nahas W, David-Neto E, Castro MC, David Daisa SR, Kalil J, Panajotopoulos N
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2011 May; Vol. 43 (4), pp. 1345-8.
DOI: 10.1016/j.transproceed.2011.03.059
Abstrakt: Preformed donor-specific human leukocyte antigen (HLA) antibodies have been associated with allograft dysfunction and failure. However, recipients of HLA-identical kidneys can develop acute humoral rejection, implicating putative pathogenic antibodies that are directed against non-HLA antigens. We investigated the presence of endothelial cell-reactive antibodies in 11 patients who experienced early loss of their transplanted kidneys owing to humoral rejection and 1 loss from renal venal thrombosis. We examined the potential efficacy of intravenous immunoglobulin to block the binding of these antibodies, as previously suggested for anti-HLA antibodies.
(Copyright © 2011. Published by Elsevier Inc.)
Databáze: MEDLINE
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