Sensitive and selective detection of zinc ions in neuronal vesicles using PYDPY1, a simple turn-on dipyrrin.
| Autor: | Mei Y; Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131, USA., Frederickson CJ, Giblin LJ, Weiss JH, Medvedeva Y, Bentley PA |
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| Jazyk: | angličtina |
| Zdroj: | Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2011 Jul 07; Vol. 47 (25), pp. 7107-9. Date of Electronic Publication: 2011 May 26. |
| DOI: | 10.1039/c1cc12181b |
| Abstrakt: | A new class of in vitro Zn(II) chemosensor based on dipyrrin has been developed. 5-(Pyren-1-yl)-4,6-dipyrrin (PYDPY1) was synthesized and exhibited high selectivity and sensitivity to Zn(II) (K(d) of 20 μM) compared to other metal ions. PYDPY1 was applied to the visualization of Zn(II) concentration in hippocampal tissue. (This journal is © The Royal Society of Chemistry 2011) |
| Databáze: | MEDLINE |
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