| Autor: |
Bassi EJ; Ênio José Bassi, Niels Olsen Saraiva Câmara, Laboratory of Transplantation Immunobiology, Department of Immunology, Universidade of São Paulo, 05508-900 São Paulo, Brazil., Aita CA, Câmara NO |
| Jazyk: |
angličtina |
| Zdroj: |
World journal of stem cells [World J Stem Cells] 2011 Jan 26; Vol. 3 (1), pp. 1-8. |
| DOI: |
10.4252/wjsc.v3.i1.1 |
| Abstrakt: |
Multipotent mesenchymal stromal cells (MSC) can be isolated and efficiently expanded from almost every single body tissue and have the ability of self-renewal and differentiation into various mesodermal cell lineages. Moreover, these cells are considered immunologically privileged, related to a lack of surface expression of costimulatory molecules required for complete T cell activation. Recently, it has been observed that MSC are capable of suppressing the immune response by inhibiting the maturation of dendritic cells and suppressing the function of T lymphocytes, B lymphocytes and natural killer cells in autoimmune and inflammatory diseases as a new strategy for immunosuppression. The understanding of immune regulation mechanisms by MSC is necessary for their use as immunotherapy in clinical applications for several diseases. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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