Review of biological mechanisms and pharmacological treatments of comorbid PTSD and substance use disorder.

Autor: Norman SB; University of California San Diego School of Medicine, San Diego, CA 92161, USA. snorman@ucsd.edu, Myers US, Wilkins KC, Goldsmith AA, Hristova V, Huang Z, McCullough KC, Robinson SK
Jazyk: angličtina
Zdroj: Neuropharmacology [Neuropharmacology] 2012 Feb; Vol. 62 (2), pp. 542-51. Date of Electronic Publication: 2011 May 13.
DOI: 10.1016/j.neuropharm.2011.04.032
Abstrakt: Posttraumatic stress disorder (PTSD) and alcohol/substance use disorder (A/SUD) are frequently comorbid. Comorbidity is associated with poorer psychological, functional, and treatment outcomes than either disorder alone. This review outlines biological mechanisms that are potentially involved in the development and maintenance of comorbid PTSD and A/SUD including neurotransmitter and hypothalamic-pituitary-adrenal dysregulation, structural differences in the brain, and shared genetic risk factors. The literature regarding pharmacological treatments that have been investigated for comorbid PTSD and A/SUD is also reviewed. Empirical data for each proposed mechanism and pharmacological approach is reviewed with the goal of making recommendations for future research. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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