| Autor: |
Gumbo FZ; Department of Paediatrics and Child Health, College of Health Sciences, University of Zimbabwe, P Bag A178, Avondale, Harare, Zimbabwe. zvanyadz@mweb.co.zw, Kandawasvika GQ, Duri K, Mapingure MP, Kurewa NE, Nathoo K, Rusakaniko S, Chirenje MZ, Stray-Pedersen B |
| Jazyk: |
angličtina |
| Zdroj: |
Tropical doctor [Trop Doct] 2011 Jul; Vol. 41 (3), pp. 132-5. Date of Electronic Publication: 2011 May 16. |
| DOI: |
10.1258/td.2011.100458 |
| Abstrakt: |
Several studies indicate that HIV-infected women continue to have children. We set out to determine the trend in HIV transmission at subsequent pregnancies. From 2002-2003, pregnant women were enrolled in a single dose nevirapine-based Prevention of Mother-to-Child Transmission of HIV (PMTCT) programme. Six years later, women with subsequent children in this cohort were identified and their children's HIV status determined. From 330 identified HIV-infected mothers, 73 had second/subsequent children with HIV results. Of these, nine (12.3%, 95% confidence interval [CI]: 4.6-20.1%) children were HIV-infected. Of the 73 second children, 51 had older siblings who had been initially enrolled in the study with definitive HIV results with an infection rate of 17/51 (33.3%, 95% CI: 19.9-46.7). About 35% of the women had been on antiretroviral drugs. These results demonstrate lower subsequent HIV transmission rates in women on a national PMTCT programme in a resource-poor setting with the advent of antiretroviral therapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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