| Autor: |
Gordon L; LAKESIDE VET ADM MED CTR,CHICAGO,IL 60611., Shapiro G, Rosen S, Kies M, Prachand S, Vriesendorp H |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of oncology [Int J Oncol] 1993 Jun; Vol. 2 (6), pp. 981-4. |
| DOI: |
10.3892/ijo.2.6.981 |
| Abstrakt: |
Peripheral blood or bone marrow cells of 15 patients with chronic lymphocytic leukemia (CLL) were separated on an albumin density gradient. In 5 of 5 CLL patients, the distribution of malignant B lymphocytes was similar across the gradient when blood and bone marrow were compared, but different from the distribution of cells from healthy volunteers. In 10 patients, B cell colony formation was measured in vitro from peripheral blood cells after gradient fractionation. Although most of the cells in all patients were found in fraction 4, the majority of B-lymphocyte colonies were found in light density fractions (1+2, 3) in patients with more advanced disease (Rai stages 3 or 4), and in heavier fractions (4, bottom) in patients with less advanced disease (Rai stages 0, 1 or 2). The density of CLL cells might provide a new prognostic marker in this disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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