Late relapse of germ cell tumors.
| Autor: | Oldenburg J; Department of Oncology, The Norwegian Radium Hospital, Oslo, Norway. jan.oldenburg@medisin.uio.no, Lorch A, Fosså SD |
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| Jazyk: | angličtina |
| Zdroj: | Hematology/oncology clinics of North America [Hematol Oncol Clin North Am] 2011 Jun; Vol. 25 (3), pp. 615-26, x. |
| DOI: | 10.1016/j.hoc.2011.03.006 |
| Abstrakt: | This article highlights relevant aspects of the rare late relapses of malignant germ cell tumors (MGCTs), which by definition occur at least 2 years after successful treatment. In most reports, 1% to 6% of patients with MGCT experience a late relapse. Surgery is the most important part in the treatment of late relapses. Viable MGCT or teratoma with malignant transformation may require multimodal treatment with chemotherapy, radiotherapy, and/or surgery. Salvage chemotherapy should be based on a representative biopsy. Referring patients with late relapse to high-volume institutions ensures the best chances of cure and enables multimodal treatment. (Copyright © 2011 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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