Analysis of fexofenadine in pharmaceutical formulations using tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate chemiluminescence system in a multichip device.

Autor: Al Lawati HA; Department of Chemistry, College of Science, Sultan Qaboos University, Box 36, Al-Khod, 123, Oman. haiderl@squ.edu.om, Al Dahmani ZM, Suliman FE, Al Kindy SM, Al-Lawati AM
Jazyk: angličtina
Zdroj: Luminescence : the journal of biological and chemical luminescence [Luminescence] 2011 Nov-Dec; Vol. 26 (6), pp. 762-7. Date of Electronic Publication: 2011 May 09.
DOI: 10.1002/bio.1310
Abstrakt: A simple, rapid and sensitive method has been developed for the analysis of fexofenadine (FEX) in pharmaceutical formulations, using a tris(1,10-phenanthroline)-ruthenium(II) [Ru(phen)(3)(2+)] peroxydisulphate chemiluminescence (CL) system in a multichip device. Various parameters that influence the CL signal intensity were optimized. These included pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve in the range 0.05-5.0 µg/mL was obtained. The detection limit was found to be 0.001 µg/mL. The procedure was applied to the analysis of FEX in pharmaceutical products and was found to be free from interference from concomitants usually present in these preparations.
(Copyright © 2011 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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