Immunization with a poly (lactide co-glycolide) encapsulated plasmid DNA expressing antigenic regions of HPV 16 and 18 results in an increase in the precursor frequency of T cells that respond to epitopes from HPV 16, 18, 6 and 11.

Autor: Matijevic M; Eisai Inc., Andover, MA 01810, USA. mark_matijevic@eisai.com, Hedley ML, Urban RG, Chicz RM, Lajoie C, Luby TM
Jazyk: angličtina
Zdroj: Cellular immunology [Cell Immunol] 2011; Vol. 270 (1), pp. 62-9. Date of Electronic Publication: 2011 Apr 23.
DOI: 10.1016/j.cellimm.2011.04.005
Abstrakt: A phase II trial was conducted in subjects with human papillomavirus (HPV) associated high-grade cervical dysplasia testing the safety and efficacy of a microparticle encapsulated pDNA vaccine. Amolimogene expresses T cell epitopes from E6 and E7 proteins of HPV types 16 and 18. An analysis was performed on a subset of HLA-A2+ subjects to test whether CD8+ T cells specific to HPV 16, 18, 6 and 11 were increased in response to amolimogene immunization. Of the 21 subjects receiving amolimogene, 11 had elevated CD8+ T cell responses to HPV 16 and/or 18 peptides and seven of these also had increases to corresponding HPV 6 and/or 11 peptides. In addition, T cells primed and expanded in vitro with an HPV 18 peptide demonstrated cross-reactivity to the corresponding HPV 11 peptide. These data demonstrate that treatment with amolimogene elicits T cell responses to HPV 16, 18, 6 and 11.
(Copyright © 2011 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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