Dietary insulin index and insulin load in relation to biomarkers of glycemic control, plasma lipids, and inflammation markers.
| Autor: | Nimptsch K; Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. knimptsc@hsph.harvard.edu, Brand-Miller JC, Franz M, Sampson L, Willett WC, Giovannucci E |
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| Jazyk: | angličtina |
| Zdroj: | The American journal of clinical nutrition [Am J Clin Nutr] 2011 Jul; Vol. 94 (1), pp. 182-90. Date of Electronic Publication: 2011 May 04. |
| DOI: | 10.3945/ajcn.110.009555 |
| Abstrakt: | Background: Dietary glycemic index and load are widely used to estimate the effect of carbohydrate-containing foods on postprandial blood glucose concentrations and as surrogates for insulin response. The food insulin index (II) directly quantifies the postprandial insulin secretion of a food and takes into account foods with a low or no carbohydrate content. Objective: We investigated the average dietary II and insulin load (IL) in relation to biomarkers of glycemic control, plasma lipids, and inflammation markers. Design: In a cross-sectional setting and with the use of data from the Nurses' Health Study and the Health Professionals Follow-Up Study, we measured plasma concentrations of C-peptide, glycated hemoglobin (Hb A(1c)), HDL cholesterol, LDL cholesterol, triglycerides, C-reactive protein (CRP), and interleukin-6 (IL-6) in fasting blood samples of 4002 healthy men and women. The dietary II and IL were assessed from food-frequency questionnaires by using directly analyzed or published food II data. Results: After multivariate adjustment, participants in the highest quintile of II had 26% higher triglyceride concentrations than did participants in the lowest quintile of II (P for trend < 0.0001). This association was strongest in obese [body mass index (in kg/m(2)) ≥30] participants (difference between highest and lowest quintiles in the II: 72%; P for trend = 0.01). Dietary II was inversely associated with HDL cholesterol in obese participants (difference: -18%; P for trend = 0.03). Similar associations were seen for the IL. Dietary II and IL were not significantly associated with plasma C-peptide, Hb A(1c), LDL cholesterol, CRP, or IL-6. Conclusion: Dietary II and IL were not associated with fasting biomarkers of glycemic control but may be physiologically relevant to plasma lipids, especially in obese individuals. |
| Databáze: | MEDLINE |
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