| Autor: |
Neale ML; Department of Medical Microbiology, University of Wales College of Medicine, Heath Park, Cardiff, UK., Fiera RA, Matthews N |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of cancer [Int J Cancer] 1990 Jan 15; Vol. 45 (1), pp. 203-8. |
| DOI: |
10.1002/ijc.2910450136 |
| Abstrakt: |
A plastic-adherent variant of human myelomonocytic leukaemia cells (U937) is highly susceptible to direct TNF cytolysis in vitro. Previously, we found that a subline selected for resistance to TNF cytolysis (U937/R) was much less motile and more plastic-adherent than the parental line. In the present study we show that U937 and U937/R cells have different glycoforms of a 105-kDa cell-surface glycoprotein. This protein is predominantly N-glycosylated and has the physicochemical properties of the LAMP-I glycoprotein. In nude mice, U937 cells are highly malignant whereas U937/R cells form a benign, encapsulated tumour. Therefore, possession of a different glycoform of the 105-kDa glycoprotein by U937/R cells correlates not only with loss of TNF susceptibility but also with reduced invasiveness and metastasis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text