Health outcome measures in atopic dermatitis: a systematic review of trends in disease severity and quality-of-life instruments 1985-2010.
| Autor: | Rehal B; Department of Dermatology, University of California Davis, Davis, California, United States of America., Armstrong AW |
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| Jazyk: | angličtina |
| Zdroj: | PloS one [PLoS One] 2011 Apr 13; Vol. 6 (4), pp. e17520. Date of Electronic Publication: 2011 Apr 13. |
| DOI: | 10.1371/journal.pone.0017520 |
| Abstrakt: | Background: A number of disease-severity and quality-of-life (QoL) instruments have emerged in atopic dermatitis (AD) in the last decade. Objectives: To identify trends in outcomes instruments used in AD clinical trials and to provide a useful summary of the dimensions and validation studies for the most commonly used measures. Method: All randomized control trials (RCTs) from 1985 to 2010 in the treatment of AD were examined. Results: Among the 791 RCTs reviewed, we identified 20 disease-severity and 14 QoL instruments. Of these outcomes instruments, few have been validated. SCORAD, EASI, IGA and SASSAD were the most commonly used disease-severity instruments and CDLQI, DFI, DLQI and IDQOL were the most frequently used QoL measures. Limitations: The small number of RCTs using QoL scales makes identifying trends for QoL instruments difficult. Conclusion: Overall, there is an increase in the use of disease-severity and QoL instruments in AD clinical trials. |
| Databáze: | MEDLINE |
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