CD4(+)CD25(high)CD127(low) regulatory T cells in patients with stable angina and their dynamics after intracoronary sirolimus-eluting stent implantation.

Autor: Potekhina AV; Russian Cardiology Research Center, Third Cherepkovskaya str., 15A, Moscow 121552, Russia. potehina@gmail.com, Provatorov SI, Sokolov VO, Pylaeva EA, Masenko VP, Noeva EA, Kukhtina NB, Krasnikova TL, Arefieva TI
Jazyk: angličtina
Zdroj: Human immunology [Hum Immunol] 2011 Jul; Vol. 72 (7), pp. 553-7. Date of Electronic Publication: 2011 Apr 14.
DOI: 10.1016/j.humimm.2011.03.015
Abstrakt: Rapamycin contributes to the expansion of regulatory T cells (Tregs) in vitro. We investigated CD4(+)CD25(high)CD127(low) Treg level dynamics as well as the major parameters of cell immunity and sCD25 and highly sensitive C-reactive protein (hsCRP) concentrations in the blood of patients after coronary stenting (CS) with sirolimus (rapamycin)-eluting stents (SES; n = 43). The relation between initial Treg values and the severity of coronary atherosclerosis was observed. Treg and sCD25 levels were increased 1 month after CS versus baseline values and versus data in the control group (coronary angiography [CA], n = 20). A positive correlation between Treg and sCD25 levels was reported, whereas no relation was observed with the length of SES implanted. HsCRP level was increased during the first 7 days and returned to baseline values 1 month after CS/CA. Treg content is lower in patients with multivessel CAD. Elevated levels of Tregs and sCD25 after SES implantation might occur because of the immunomodulating effect of rapamycin.
(Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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