| Autor: |
Cassarmalek I; INRA,LAB DIFFERENCIAT CELLULAIRE & CROISSANCE,UNITE ENDOCRINOL CELLULAIRE,F-34060 MONTPELLIER 1,FRANCE. ECOLE NORMALE SUPER LYON,INRA,LAB BIOL MOL & CELLULAIRE,CNRS,UMR 40,F-69364 LYON,FRANCE., Marchal S, Rochard P, Wrutniak C, Samarut J, Cabello G |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of oncology [Int J Oncol] 1997 Nov; Vol. 11 (5), pp. 1095-101. |
| DOI: |
10.3892/ijo.11.5.1095 |
| Abstrakt: |
We have previously shown that v-erb A stimulates quail myoblast differentiation in a T3 independent, cell-specific manner. In this work, we have studied the influence of v-erb B (the second oncogene carried in the AEV genome) upon quail myoblast proliferation and differentiation. v-erb B expression,moderately stimulates myoblast proliferation, and inhibits differentiation. Moreover, this oncoprotein fully inhibits the v-erb A myogenic influence. These data provide evidence that these two oncogenes do not cooperate in avian myoblasts. Consequently, in contrast to results obtained in other cell-types, coexpression of both oncogenes does not transform quail myoblasts. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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