[In vitro study, in perfused rabbit heart, of interaction between two anti-arrhythmia agents: amiodarone and disopyramide].

Autor: Akhdim H; Chaire de Pharmacologie, Faculté de Médecine et de Pharmacie, Université de Franche-Comté, Besançon., Kantelip JP, Stimmesse B, Toubin G, Magnin P
Jazyk: francouzština
Zdroj: Comptes rendus des seances de la Societe de biologie et de ses filiales [C R Seances Soc Biol Fil] 1990; Vol. 184 (5-6), pp. 329-34.
Abstrakt: The influence of 15 day's amiodarone administration (30 mg/kg/day) on myocardial uptake kinetics and electrocardiographic changes of disopyramide was examined on the isolated perfused rabbit heart (n = 24) under electrical stimulation. Amiodarone significantly reduced myocardial uptake and potentialized the effect of disopyramide on intraventricular conduction.
Databáze: MEDLINE