| Autor: |
Gorodetskiĭ VK, Tochilkin AI, Beliaeva NF, Kovel'man IR, Korovkin BF |
| Jazyk: |
ruština |
| Zdroj: |
Biomeditsinskaia khimiia [Biomed Khim] 2011 Jan-Feb; Vol. 57 (1), pp. 133-7. |
| DOI: |
10.18097/pbmc20115701133 |
| Abstrakt: |
In order to create new oral vanadyl organic complexes-based drugs for the treatment of diabetes mellitus biligand vanadyl derivative of L-malic acid (bis(L-malato)oxovanadium(IV) was prepared and its potential as a novel hypoglycemic agent was studied in the streptozotocin-diabetic rats. We show that the oral administration of bis(L-malato)oxovanadium(IV) with drink water significantly reduced glucose concentration in blood and urine, as well as the level of glycated proteins in the streptozotocin-diabetic rats. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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