| Autor: |
Avasthi TS; Department of Biotechnology, University of Hyderabad, Gachibowli, Hyderabad, India., Devi SH, Taylor TD, Kumar N, Baddam R, Kondo S, Suzuki Y, Lamouliatte H, Mégraud F, Ahmed N |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of bacteriology [J Bacteriol] 2011 Jul; Vol. 193 (13), pp. 3385-6. Date of Electronic Publication: 2011 Apr 22. |
| DOI: |
10.1128/JB.05006-11 |
| Abstrakt: |
The diverse clinical outcomes of colonization by Helicobacter pylori reflect the need to understand the genomic rearrangements enabling the bacterium to adapt to host niches and exhibit varied colonization/virulence potential. We describe the genome sequences of the two serial isolates, H. pylori 2017 and 2018 (the chronological subclones of H. pylori 908), cultured in 2003 from the antrum and corpus, respectively, of an African patient who suffered from recrudescent duodenal ulcer disease. When compared with the genome of the parent strain, 908 (isolated from the antrum of the same patient in 1994), the genome sequences revealed genomic alterations relevant to virulence optimization or host-specific adaptation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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