| Autor: |
Glennon RA; Department of Medicinal Chemistry, School of Pharmacy, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298-0540., De Vry J, Spencer DG Jr, Glaser T |
| Jazyk: |
angličtina |
| Zdroj: |
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 1990 Dec; Vol. 37 (4), pp. 769-71. |
| DOI: |
10.1016/0091-3057(90)90561-u |
| Abstrakt: |
Tiflucarbine is a structurally novel antidepressant that binds at central serotonin (5-HT) binding sites. There is also evidence that this agent is both a 5-HT1 and a 5-HT2 agonist. To further characterize the serotonergic actions of this agent, tiflucarbine was evaluated in groups of rats trained to discriminate the 5-HT1A agonist 8-OH DPAT, the 5-HT2 agonist DOM, and the nonselective 5-HT agonist 5-OMe DMT from saline. Tiflucarbine resulted in partial generalization in the DOM-trained and in the 8-OH DPAT-trained animals. Although two-thirds of the animals were disrupted, 10 mg/kg of tiflucarbine resulted in stimulus generlization in the 5-OMe DMT-trained animals. It is concluded that tiflucarbine is most likely a nonselective 5-HT agonist. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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