Efficacy of marigold extract-loaded formulations against UV-induced oxidative stress.

Autor: Fonseca YM; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil., Catini CD, Vicentini FT, Cardoso JC, Cavalcanti De Albuquerque Junior RL, Vieira Fonseca MJ
Jazyk: angličtina
Zdroj: Journal of pharmaceutical sciences [J Pharm Sci] 2011 Jun; Vol. 100 (6), pp. 2182-93. Date of Electronic Publication: 2010 Dec 23.
DOI: 10.1002/jps.22438
Abstrakt: The present study investigated the potential use of topical formulations containing marigold extract (ME) (Calendula officinalis extract) against ultraviolet (UV)B irradiation-induced skin damage. The physical and functional stabilities, as well as the skin penetration capacity, of the different topical formulations developed were evaluated. In addition, the in vivo capacity to prevent/treat the UVB irradiation-induced skin damage, in hairless mice, of the formulation with better skin penetration capacity was investigated. All of the formulations were physically and functionally stable. The gel formulation [Formulation 3 (F3)] was the most effective for the topical delivery of ME, which was detected as 0.21 μg/cm(2) of narcissin and as 0.07 μg/cm(2) of the rutin in the viable epidermis. This formulation was able to maintain glutathione reduced levels close to those of nonirradiated animals, but did not affect the gelatinase-9 and myeloperoxidase activities increased by exposure to UVB irradiation. In addition, F3 reduced the histological skin changes induced by UVB irradiation that appear as modifications of collagen fibrils. Therefore, the photoprotective effect in hairless mice achieved with the topical application of ME in gel formulation is most likely associated with a possible improvement in the collagen synthesis in the subepidermal connective tissue.
(Copyright © 2010 Wiley-Liss, Inc.)
Databáze: MEDLINE
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