| Autor: |
Brunetta DM; Hematology Division and Center for Cell Based Therapy, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, 14051-140 Ribeirao Preto, SP, Brazil., Silva-Pinto AC, do Carmo Favarin de Macedo M, Bassi SC, Piccolo Feliciano JV, Ribeiro FB, Prado Bde P Jr, De Santis GC, de Lucena Angulo I, Covas DT |
| Jazyk: |
angličtina |
| Zdroj: |
Anemia [Anemia] 2011; Vol. 2011, pp. 975731. Date of Electronic Publication: 2010 Dec 21. |
| DOI: |
10.1155/2011/975731 |
| Abstrakt: |
Intrahepatic cholestasis (SCIC) is an uncommon but potentially fatal complication of sickle cell disease (SCD), with a high death rate, observed mainly in patients with homozygous sickle cell anemia. Herein, we describe a case of severe SCIC treated successfully with aggressive manual exchange transfusion (ET). The patient was admitted with enlarged liver and signs of hepatic failure, such as hyperbilirubinemia and coagulopathy. There was no evidence of viral hepatitis or biliary obstruction. We performed several sessions of ET in order to reduce the percentage of HbS to levels inferior to 30%, which was successfully accomplished. The patient had a complete recovery of hepatic function. This case has shown that ET is an effective treatment of SCIC and should be introduced early on the onset of this severe complication. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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