Extraneuronal toxicity of Alzheimer's β-amyloid peptide: comparative study on vertebrate skeletal muscles.

Autor: Mukhamedyarov MA; Department of Physiology, Kazan State Medical University, ul. Butlerova 49, R-420012 Kazan, Russia. maratm80@list.ru, Teplov AY, Grishin SN, Leushina AV, Zefirov AL, Palotás A
Jazyk: angličtina
Zdroj: Muscle & nerve [Muscle Nerve] 2011 Jun; Vol. 43 (6), pp. 872-7. Date of Electronic Publication: 2011 Apr 12.
DOI: 10.1002/mus.22000
Abstrakt: Introduction: Alzheimer's β-amyloid peptide (βAP) is known to possess a wide range of toxic effects on neurons in vitro and in vivo; however, there is little information available regarding its impact on other excitable tissues such as skeletal muscles, which, apart from brain cells, are thought to also be targets of βAP.
Methods: Utilizing the combination of electrophysiology and myography, we investigated whether βAP also impairs the functioning of myocytes in frogs and mice.
Results: Although application of βAP in the range of 10(-6) to 10(-8) M induced depolarization of muscle fibers in both species, it impaired contractility in frogs but not in mice, by reducing endplate potential amplitude and increasing the threshold potential.
Conclusions: Unchanged contractility in the mouse in the presence of βAP is due to a higher safety factor of neuromuscular transmission in mammals compared with amphibians. Possible clinical implications are discussed.
(Copyright © 2011 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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